Donald Trump – Trump is wrong: There are downsides to avoiding Tylenol, not treating fever while pregnant

Trump’s advice is based on the unproven idea that acetaminophen use during pregnancy increases a child’s risk of autism — a stance that he and Robert F. Kennedy Jr., the longtime anti-vaccine activist Trump tapped as health secretary, touted throughout their address.^[1]

Although some studies have found that children exposed to acetaminophen during pregnancy were more likely to have autism symptoms or be diagnosed with autism, other studies found no such association. Association is not the same as causation. That means that research showing an association between Tylenol and autism doesn’t mean the medication caused autism. ^[2]

The U.S. Food and Drug Administration’s Sept. 22 press release on the topic said as much. ^[3]

“It is important to note that while an association between acetaminophen and neurological conditions has been described in many studies, a causal relationship has not been established and there are contrary studies in the scientific literature,” it said. “It is also noted that acetaminophen is the only over-the-counter drug approved for use to treat fevers during pregnancy, and high fevers in pregnant women can pose a risk to their children.” 

The White House declined to provide data showing there are no downsides to avoiding Tylenol use. It provided a statement from White House Press Secretary Karoline Leavitt in which she cited “a connection” between acetaminophen use during pregnancy and autism as the reason for the guidance.

“The Trump Administration does not believe popping more pills is always the answer for better health,” Leavitt said.

Leavitt also shared on X a statement from Dr. Andrea Baccarelli, a dean at Harvard T.H. Chan School of Public Health, who said his research “found evidence of an association” between prenatal acetaminophen exposure and neurodevelopmental disorders in children. Baccarelli warned of the risks of high fever and advocated for cautious acetaminophen use during pregnancy — not blanket avoidance.^[4]

RELATED: Fact-checking Trump’s claims on Tylenol, autism and vaccines^[5]

Acetaminophen is safe during pregnancy. Untreated fevers are not.

Maternal and prenatal care groups, including the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine, support the use of acetaminophen during pregnancy.^[6][7]

They reiterated this support again in response to or in expectation of Trump’s remarks. ^[8][9]

There’s good reason for that: Acetaminophen is one of few safe options pregnant patients have to treat fever and manage pain. 

Trump acknowledged this during the press conference. 

“Sadly, first question: What can you take instead?” he said. “There’s not an alternative.” He said that other medicines such as aspirin and Advil “are absolutely proven bad.”

President Donald Trump speaks at the White House, Sept. 22, 2025, alongside others. From left: National Institutes of Health Director Dr. Jay Bhattacharya, FDA Commissioner Dr. Marty Makary, HHS Secretary Robert F. Kennedy Jr., Centers for Medicare & Medicaid Services administrator Dr. Mehmet Oz, Dr. Dorothy Fink, acting assistant secretary for health, and Jackie O’Brien. (AP)

In 2023, the FDA advised that nonsteroidal anti-inflammatory drugs, or NSAIDs, which includes common pain relievers such as Advil, Aleve — also known as ibuprofen or naproxen, respectively — and aspirin shouldn’t be used during pregnancy after 20 weeks of gestation.^[10]

Those medications aren’t recommended during pregnancy because they could harm fetal development, Dr. Salena Zanotti, an obstetrician and gynecologist, told Cleveland Clinic earlier this year. ^[11]

Untreated fevers during pregnancy come with their own risks.

In a Sept. 22 statement, Dr. Steven J. Fleischman, ACOG’s president, said the Trump administration’s anti-Tylenol advice sends a “harmful and confusing message” to pregnant patients.^[12]

“Maternal fever, headaches as an early sign of preeclampsia, and pain are all managed with the therapeutic use of acetaminophen, making acetaminophen essential to the people who need it,” Fleischman said. 

Dr. Christopher Zahn, ACOG’s chief of clinical practice, said pregnant patients should talk with their doctors about the benefits and risks of available treatments. Avoiding treating medical conditions that call for acetaminophen is “far more dangerous than theoretical concerns based on inconclusive reviews of conflicting science,” Zahn said.^[13]

Similarly, the Society for Maternal-Fetal Medicine said that untreated fever and pain during pregnancy carries “significant maternal and infant health risks.” 

“Untreated fever, particularly in the first trimester, increases the risk of miscarriage, birth defects, and premature birth, and untreated pain can lead to maternal depression, anxiety, and high blood pressure,” it said. ^[14]

The research on this goes back more than a decade: A 2014 Pediatrics review of available evidence on fevers during pregnancy found “substantial evidence” that maternal fever might negatively affect fetal health in the short and long term, including increasing the risks of neural tube defects, congenital heart defects and oral clefts.^[15]

The U.S. Centers for Disease Control and Prevention also says that fever during pregnancy has been linked to adverse outcomes including birth defects. ^[16][17][18]

MotherToBaby, a nonprofit organization that provides information about the benefits or risks of medications and other exposures during pregnancy and while breastfeeding, warns that a fever-caused increase in body temperature during early pregnancy carries risks, including a small chance for birth defects. Some studies also found that fevers are associated with increased chances of a child having attention-deficit/hyperactivity disorder or autism.^[19][20][21]

Kenvue, Tylenol’s parent company, said acetaminophen is “the safest pain reliever” option available throughout an entire pregnancy. 

“Without it, women face dangerous choices: suffer through conditions like fever that are potentially harmful to both mom and baby or use riskier alternatives,” the company’s statement said. “High fevers and pain are widely recognized as potential risks to a pregnancy if left untreated.”

Tylenol, responding to the news attention on Instagram, cited the ACOG position on acetaminophen use during pregnancy and highlighted a section of the Tylenol label that encourages people who are pregnant or breast feeding to talk to a health professional.^[22]

“Your doctor is the best person to advise whether taking medication is right for you based on your specific health needs,” the video said.

Our ruling

Trump said “there’s no downside” to avoiding Tylenol use during pregnancy. 

Researchers have long documented health risks associated with untreated fevers during pregnancy. They can lead to increased risk of birth defects and other pregnancy complications, particularly in the first trimester. Untreated pain can lead to maternal depression, anxiety and high blood pressure. These risks outweigh conflicting research into possible links between the drug and autism, according to maternal and fetal health organizations. 

Doctors and researchers have found acetaminophen to be a safe pain and fever reducer during pregnancy. By comparison, other over-the-counter pain relievers come with documented risks, making Tylenol one of the only options available to pregnant mothers. 

We rate Trump’s statement Pants on Fire!

RELATED: Research doesn’t show using Tylenol during pregnancy causes autism. Here’s what else you should know ^[23]

RELATED: RFK Jr.’s statements about autism and environmental toxins conflict with ample research^[24]